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Tumor or Cancer Markers

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  • Tumor or Cancer Markers

    Hello all,

    Does anyone know how good of an indicator the cancer markers alpha-fetoprotein (AFP), beta human chorionic gonadotropin (BHCG) and lactate dehydrogenase (LDH) are?

    If your levels are normal or zero, does that mean you do not have tc or are these markers present in only some people with tc?

    Thanks. Everyone on this forum is great.

  • #2
    If you have raised levels of those cancer markers you almost certainly have tc, however their absence is not an indicator that you are cancer free. Pure seminoma never produces AFP and may not increase any marker at all.
    Last edited by dadmo; 01-16-07, 07:53 PM.
    Son Jason diagnosed 4/30/04, stage III. Right I/O 4/30/04. Graduated College 5/13/04. 4XEP 6/7/04 - 8/13/04. Full open RPLND 10/13/04. All Clear since.

    Treated by Dr. Rakowski of Midland Park, NJ. Visited Sloan Kettering for protocol advice. RPLND done at Sloan Kettering.


    • #3
      Seminoma can produce no markers, but also can increase levels of bHCG.

      Seminoma never produces AFP
      Diagnosed March 2006, Stage IIB, 3cm RP mass
      10% Seminoma, 90% Non-Seminoma (Embryonal, and a tiny amount of choriocarcinoma and teratoma)
      Prechemo bHCG-2648, AFP-582
      3xBEP March-June, markers normalised
      3 months postchemo - 1.2cm residual RP mass
      RPLND September 2006 - mostly necrotic tissue plus tiny amount of well differentiated teratoma
      June 2009 - TRT commenced to help out my lefty
      May 2011 - check-up, all clear