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Management of recurrent testicular germ cell tumors

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  • Management of recurrent testicular germ cell tumors

    Summarizes salvage protocols from key centers throughout the world, and the current prognoses. Seminoma and non-seminona disussed. Link to full text article worth a read, although it may be emotionally difficult to do so.

    Oncologist. 2007 Jan;12(1):51-61.
    Management of recurrent testicular germ cell tumors.Sonpavde G, Hutson TE, Roth BJ.
    US Oncology Research, Houston, Texas, USA. [email protected]

    Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%-50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage surgical resection has an important role in selected patients. Cisplatin-refractory patients have a poor prognosis with current therapy, and novel chemotherapeutic and biologic agents need to be discovered for such patients.
    Retired moderator. Husband, left I/O 16Dec2005, stage I seminoma with elevated b-HCG, no LVI, RTx15 (25Gy). All clear ever since.