A layman's primer on TC chemo

[Fed]

Over the last several weeks, I have put together a primer on the chemo agents that are used in the treatment of testicular cancer. This primer is aimed at explaining why certain side effects occur while delving a little bit into the biological aspects of their function. In a sense, I want to showcase a little bit of the science while trying to serve as a guide to guys undergoing BEP treatment.

One of the wonders of the WWW is the ability to edit things promptly. If there are terms that don't make sense, or if you find any errors or confusing terms, let me know so I can look into the issue swiftly.

Finally, I want to acknowledge the other mods for their help with this. My fellow geek Karen helped bring me down to earth with the jargon, and Scott and Bill made contributions to its readability to the non-scientist.

The primer can be found here. I hope you find it useful.

[Already Bald]

Well done Fed.
As a layman and a patient, I can tell you my chemo experience was not a walk in the park.
In fact, I am still slightly anemic- even now ten months post chemo. This is something that my doc watches. Makes me that much prouder of my 40 miles!

I do have a question for you:

Did your research uncover the factors that determine the actual dosages prescribed? Is it possible that a less experienced facility may over infuse a patient, when following standard protocals? In other words, infuse more chemo than actually necessary.

[John S]

Fed,

Great job with keeping it understandable. I work with a number of researchers and they typically have great dificulty communicating in laymans terms.
Does the XRT and carboplatinum also work by disrupting the DNA?

[Fed]

Does the XRT and carboplatinum also work by disrupting the DNA?

Carboplatin works exactly like cisplatin, the difference being that carboplatin binds to DNA a bit more weakly than cisplatin. Because of the weaker binding, carboplatin is not as potent as cisplatin, but as a consequence, it produces fewer side effects, a trait that makes it attractive for use in high dose regimens.

XRT causes damage to DNA, especially when cells are dividing. All cells have a signaling system that detects damage to DNA and instructs the cell to fix it. If the damage is too overwhelming, the same signaling system instructs the cell to self-destruct. Coincidentally, my research involves finding ways to control this signaling system when it's defective (about 50% of all cancer cells have these problems).

[starjayroman]

Fed,
Do you know about the high dose chemos?? Like Vinorelbine (Navelbine) and Ifosfamide ?That is what Jay is currently getting along with Cisplatin. Is it the standard VIP for salvage chemo?? He is also getting Mesna and all the counteractive meds they give him. Because of one of the drugs he is getting shots of insulin. He has three today. I am worried about what might happen when he is home alone with our son during Nadir and I am at work. I am already making sure that Chris knows to dial 911 and give our address. I am also trying to find a place to learn CPR. I also need to find a support group for our son that has kids going through similar things. He couldn't sleep last night worrying about dad.

[Fed]

Do you know about the high dose chemos??

There are two types of HDC regimens. One is carboplatin and etoposide given at 7-10 times the regular doses. The second consist of two phases: an induction with taxol and ifosfamide/mesna followed by consolidation with carboplatin and etoposide given at 4-6 times the regular doses.

Like Vinorelbine (Navelbine) and Ifosfamide ?That is what Jay is currently getting along with Cisplatin. Is it the standard VIP for salvage chemo?? He is also getting Mesna and all the counteractive meds they give him.

Typically, salvage regimens use vinblastine, ifosfamide and platinum (VeIP) or taxol, ifosfamide and platinum (TIP). VIP is now considered a first-line treatment for patients that could show toxicity to bleomycin.

I am worried about what might happen when he is home alone with our son during Nadir and I am at work. I am already making sure that Chris knows to dial 911 and give our address. I am also trying to find a place to learn CPR. I also need to find a support group for our son that has kids going through similar things. He couldn't sleep last night worrying about dad.

Great call on giving instructions to your son. The burden cancer has on kids of patients is evident at all ages, and that is a difficult struggle. Perhaps your local cancer center has information on support groups for kids (I know we have them at Dana-Farber).

[CancerSux]

Coincidentally, my research involves finding ways to control this signaling system when it's defective (about 50% of all cancer cells have these problems).

Fed - do you work on p53? Just reading this 'sticky' thread and saw your reference to controlling apoptosis vs proliferation and thought it sounded like it ...

Best wishes,
Tracy

[Fed]

Fed - do you work on p53? Just reading this 'sticky' thread and saw your reference to controlling apoptosis vs proliferation and thought it sounded like it ...

Bingo! My lab researches chemical methods of modulating protein-protein interactions, and reactivation of p53 function is the centerpiece of my group's work.

[CancerSux]

Bingo! My lab researches chemical methods of modulating protein-protein interactions, and reactivation of p53 function is the centerpiece of my group's work.

Nice! That is what I thought by the description.

My lab focuses on secondary DNA structures induced by supercoiling and using them as druggable targets for oncogenes - mostly for MYC ... kind of pharmacology and chemical (structural really) biology combined.

[julesTO]

Hi Trace & Fed,

I have a friend who's an MD and is interested in transitioning into a research type roll. Just wondering what paths you took (academic or otherwise) to get into your respective careers? Any thoughts on how a general practitioner could get into your field?

Thanks!

[CancerSux]

Jules,

We are on the road to MS right now, but I will send you a PM when we get into Texas tonight at our first stop about it ... IMO, MDs can transition into research pretty well...

Tracy

[julesTO]

Thanks Tracy - glad to hear you're all packed up and on the move. I'll look forward to hearing an update. Good luck

[kaylee]

link is broken

Over the last several weeks, I have put together a primer on the chemo agents that are used in the treatment of testicular cancer. This primer is aimed at explaining why certain side effects occur while delving a little bit into the biological aspects of their function. In a sense, I want to showcase a little bit of the science while trying to serve as a guide to guys undergoing BEP treatment.

One of the wonders of the WWW is the ability to edit things promptly. If there are terms that don't make sense, or if you find any errors or confusing terms, let me know so I can look into the issue swiftly.

Finally, I want to acknowledge the other mods for their help with this. My fellow geek Karen helped bring me down to earth with the jargon, and Scott and Bill made contributions to its readability to the non-scientist.

The primer can be found here. I hope you find it useful.

Hey, did you put this on a new site? I'm trying to access it but the link seems to be broken. Thanks!

[hbr777]

Hey, did you put this on a new site? I'm trying to access it but the link seems to be broken. Thanks!

The link is 8 years old. I am not surprised it is gone

[CancerSux]

I'll ask Fed if he still has it.

T