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  • Recurrence/Relapse

    Is there a difference in meaning between these two terms when reading clinical studies? For instance on TCRC when Dr. Craig Nic. talks about patients with clinical non-sem. stage II that have the rplnd and two courses of BEP virtually never have a recurrence. He he not talking about late relapses?
    May 2000 I/O 100% Emb. Carc./June 2000 RPLND, 1 Node with Micro Involvement/ July 2000 1xBEP, 1xEP

  • #2
    I think both terms are interchangeable.
    "Life moves pretty fast; if you don't stop and look around once in a while, you could miss it." -Ferris Bueller
    11.22.06 -Dx the day before Thanksgiving
    12.09.06 -Rt I/O; 100% seminoma, multifocal; Stage I-A; Surveillance; Six years out! I consider myself cured.

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    • #3
      Ditto. Relapse and recurrence are synonyms.
      Scott
      right inguinal orchiectomy 6/5/2003 > nonseminoma, stage I > surveillance > L-RPLND 6/24/2005 for recurrence, suspected teratoma but found seminoma, stage II > chylous ascites until 9/2005 > surveillance and "all clear" since

      Your donation funds Livestrong services for people facing cancer now. Please sponsor my ride!

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      • #4
        thanks guys.

        I've just been doing research on late replases. It seem to happen roughly 2 percent of the time however it seems that most of these articles note that stage II patients that have had a successful rplnd + 2 cycles of bep seem to never relapse.

        I hope they are right
        May 2000 I/O 100% Emb. Carc./June 2000 RPLND, 1 Node with Micro Involvement/ July 2000 1xBEP, 1xEP

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        • #5
          .

          NonSeminoma [NS] has a greater rate of relapse than seminoma within first 2 years. But, late relapses has been oberved especialy in seminoma and unresected teratoma cases [even after 15 years]. RPLND avoid any late abdominal lymph node relapse. Therefore, I agree that in stage II NS, 2xBEP + RPLND has a very,very low rate of late relapse [but not 0 !]. RPLND eliminates the posible abdominal recurrence sites and 2xBEP cleanup the whole system from any vascular invasion.
          I hate RPLND ! [I never had and I hope never will]
          2005-03
          Stage III EC 85% + Sem 15%
          AFP=2.6; HCG=10, 20,28 and rising
          FULL CAT scan:
          -abdominal lymph clear
          -subpleural lungs metastasis [bipulmonary lesions with diam <= 1cm]
          4 x BEP changed to 3 x BEP at my request
          from 2005-05....Surveillance

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          • #6
            I hope you never have to go through the rplnd also. I did the hockey stick incision where they take out a rib. This has created a lot back and rib pain till this day. Some guys seem to recover better than others though.
            May 2000 I/O 100% Emb. Carc./June 2000 RPLND, 1 Node with Micro Involvement/ July 2000 1xBEP, 1xEP

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            • #7
              A cancer remission is a disappearance of its symptoms and its signs. It can either be partial or complete. Cure, in its strictest of definitions, would mean that it's completely gone and the chances of a recurrence are zero (or near zero).
              "Life moves pretty fast; if you don't stop and look around once in a while, you could miss it." -Ferris Bueller
              11.22.06 -Dx the day before Thanksgiving
              12.09.06 -Rt I/O; 100% seminoma, multifocal; Stage I-A; Surveillance; Six years out! I consider myself cured.

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              • #8
                I believe that for non-seminoma patients you are in remission when you have no signs of cancer an you are considered cured when you pass two years of remission.
                Son Jason diagnosed 4/30/04, stage III. Right I/O 4/30/04. Graduated College 5/13/04. 4XEP 6/7/04 - 8/13/04. Full open RPLND 10/13/04. All Clear since.

                Treated by Dr. Rakowski of Midland Park, NJ. Visited Sloan Kettering for protocol advice. RPLND done at Sloan Kettering.

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                • #9
                  Dr. Einhorn told us Jon was in remission from the day his HCG normalized and after two years it is considered cured.

                  Jon also had a lot of teratoma and the time frame for cure is 5 years instead of 2.
                  Lori and Jon
                  Diagnosed 5/22/2006
                  I/O 5/26/2006, Stage 3, Good
                  Teratoma (Majority), Seminoma (10%), Yolk Sac
                  3xEP then determined not working
                  HDC w/stem cell transplant 8/16/06 to 9/25/06
                  Chest and Neck surgery 10/9/06 - immature teratoma
                  RPLND 11/16/06 - immature Teratoma
                  2/29/2008 - markers continue to be normal!
                  9/16/2008 - released from Dr. Einhorn's care

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