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Article: Fertility after testicular cancer treatments

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  • Article: Fertility after testicular cancer treatments

    Fertility after testicular cancer treatments

    Results of a large multicenter study
    Eric Huyghe, M.D. 1 2, Tomohiro Matsuda, M.Sc. 1, Myriam Daudin, M.D. 1 3, Christine Chevreau, M.D. 4, Jean-Marc Bachaud, M.D. 4, Pierre Plante, M.D. 1 2, Louis Bujan, M.D. 1 3, Patrick Thonneau, M.D., M.Sc., Ph.D. 1 *
    1Human Fertility Research Group, Paule de Viguier Hospital, Toulouse, France
    2Urology Department, Rangueil Hospital, Toulouse, France
    3Regional Semen Banking Unit, Centre Etude et de Conservation de Sperme (CECOS) Midi-Pyrénées, La Grave Hospital, Toulouse, France
    4Claudius Regaud Cancer Institute, Toulouse, France

    email: Patrick Thonneau ([email protected])

    *Correspondence to Patrick Thonneau, Human Fertility Research Group, Paule de Viguier Hospital, 330 Avenue de Grande Bretagne, TSA 70034, 31059 Toulóuse Cedex 9, France

    Fax. (011) 33 567771043

    Funded by:
    French National Institute of Health and Medical Research
    Fondation pour la Recherche Medicale
    CECOS Midi-Pyrénées

    testicular cancer • fertility • chemotherapy • radiotherapy


    Patients with testicular cancer have an excellent survival rate, and fertility is one of the main concerns of survivors. The authors investigated fertility status after treatment for testis cancer in long-term survivors.

    Four hundred fifty-one consecutive patients with testicular cancer (1979-1999) from health facilities in the French Midi-Pyrenees region were enrolled. Testis tumors were classified according to the Royal Marsden Hospital Classification. Fertility status was assessed by means of a mailed, standardized questionnaire focused on reproductive events that occurred before and after treatment. Of 451 patients with germ-cell tumors, information concerning fertility was obtained in 446 patients (98.9%). The follow-up was at least 3 years.

    Before they were diagnosed with testicular cancer, 91.2% of patients who had tried to get their partners pregnant had succeeded, compared with 67.1% of patients after treatment. Radiotherapy had a much more deleterious effect on fertility compared with chemotherapy alone. Furthermore, cumulative conception rates (log-rank test) for patients who received radiotherapy were significantly lower compared with the rates for patients who received chemotherapy.

    The outcome of this study, which included the largest series reported to date, showed that fertility in patients with testicular cancer decreased by 30% after treatments and that radiotherapy seemed to have the most deleterious effect on fertility. Cancer 2004;100:732-7. © 2004 American Cancer Society.

  • #2
    Okay, not a surprise there

    Well that isn't surprising. But I am going to have fertility tests performed in a month or so to help me and the fiancee with family planning(aka: what kind and how much birth control we'll need.) The only problem I have with these studies is that they don't apply to me very easily, most of the chemo's are shorter duration and lower dose with fewer drugs. Just based on the damage to my Testosterone production I am not holding out much hope for good fertility, I just hope I have enough to freeze for a rainy day But it is nice to see numbers so that I know I'll be facing a more difficult time whenever we do decide to try for a family, I'll be more mentally prepared at least. Has anyone on here had problems after larger doses of chemo w/out radiation? Just wondering and I figured the collective here would know more

    Thanks much,

    Orchiectomy in Jan 2001 for what turned out to be Teratoma and PNET tumor in left testicle. 18 rounds of Chemotherapy for 11 months, five drugs(Cisplatin, Doxorubicin, Etoposide, Ifosfamide, and Vincristine). 3 years cancer free as of February 2005