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T Gel plus DMPA is a Promising Male Contraceptive

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  • T Gel plus DMPA is a Promising Male Contraceptive

    Interesting article in Nov. 2006 Endocrine News. Paraphrasing, it says a team of scientists hypothesized that testosterone transdermal gel (T gel) could be combined with a depot formulation of depomedroxy-progesterone acetate (DMPA) to conveniently, rapidly, and reversibly suppress spermatogenesis. To test their hypothesis they randomized 44 healthy men aged 18-55 to a 24 week treatment regiment of T gel plus DMPA and found that all experienced dramatic spermatogenesis suppression, and 90% of the subjects became severely oligospermic. This rate is comparable to implantable and injectable testosterone/progestin combinations. No serious adverse events and only minimal changes in weight, serum lipds and PSA occurred. The scientists conclude that T gel plus DMPA is a promising new male contraception regimen. It will be interesting to find out how many guys would be willing to take this stuff. Dianne
    Spouse: I/O 8/80; embryonal, seminoma, teratoma; RPLND 9/80 - no reoccurrence - HRT 8/80; bladder cancer 11/97; reoccurrence: 4X
    Son: I/O 11/04; embryonal, teratoma; VI; 3XBEP; relapse 5/08; RPLND 6/18/08 - path: mature teratoma

  • #2
    There is a professor in Sydney who is doing trials on this with T pellets, I think its a good option for short term male birth control although I dont see why DMPA is neccesary.
    Aged 23 ;; 09/06 left I/O ;; Markers normal ;; 100% Seminoma Stage 1. ;; 10x8x16mm & 7x7x8mm ;; rete testis invasion. ;; no vascular invasion. ;; surveillance. ;; HRT.


    • #3
      Earlier research involving suppressing Testosterone as a birth control measure did not work. Perhaps this is why DMPA is being added.

      The Testosterone Deficiency Centre

      Associate Editor
      The Testicular Cancer Resource Center

      Director and writer
      A Ball Dropped