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  • internal bleeding?

    buddy is at sloan overnite,hemoglobin counts low...they suspect internal bleeding.what could this be caused by?is it most likely chemo related?

  • #2
    It's quite possible. You whole intestinal tract becomes very sensitive from the intake to the output. Anything that could cut (nut, seed) or burn (mexican food) could cause a problem.
    Last edited by dadmo; 04-05-06, 07:59 AM.
    Son Jason diagnosed 4/30/04, stage III. Right I/O 4/30/04. Graduated College 5/13/04. 4XEP 6/7/04 - 8/13/04. Full open RPLND 10/13/04. All Clear since.

    Treated by Dr. Rakowski of Midland Park, NJ. Visited Sloan Kettering for protocol advice. RPLND done at Sloan Kettering.

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    • #3
      i was thinking urinary tract possibly?

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      • #4
        There is a good chance it is the chemo. The chemo could have caused a tumor to hemmorage, or a tumor could have hemoraged on its own. Any results with the new chemo drug?

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        • #5
          ok...the bleeding is being caused by the massive abdominal tumors growth,which is perforating a hole in his stomach causing ulcer-like symptoms.he is being rushed to Yale for radiation to attempt to shrink the tumor.he cannot partake in the clinical trial,until the bleeding has stopped.since non-seminatomous tumors arent effected by radiation,i assume he will never be able to try the bms-247550.but why then,are they trying it?

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          • #6
            From what I recall, there might be a slight response to radiation. It is used to treat CNS ( central nervous system) germ cell tumors. I don't know what the exact elgibility is for the clinical trial he is on. I did a search on clinicaltrials.gov and couldn't find the trial. ON the MSKCC website there is limited info. Has he received a dose or not? The most important thing now is to treat the direct cause of the bleeding with radation / surgery but I would assume hes not healthy enough to go through surgery. He might also be treated with the drug off trial, but that would be rare in his case.

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            • #7
              OK I found the trial, the drug is also known as ixabepilone. One reason he might be taken off trial is his Karnofsky score which is based on his symptoms. They require a score of at least 70%


              100 % Normal no complaints; no evidence of disease.
              90 % Able to carry on normal activity; minor signs or symptoms of disease.
              80 % Normal activity with effort; some signs or symptoms of disease.
              70% Unable to work; able to live at home and care for most personal needs; varying amount of assistance needed.


              Some info from Medscape

              "BMS-247550 is a semisynthetic analogue of the natural product epothilone B and has a mode of action analogous to that of paclitaxel (i.e., microtubule stabilization). In vitro, it is twice as potent as paclitaxel in inducing tubulin polymerization. Like paclitaxel, BMS-247550 is a highly potent cytotoxic agent capable of killing cancer cells at low nanomolar concentrations. Importantly, BMS-247550 retains its antineoplastic activity against human cancers that are naturally insensitive to paclitaxel or that have developed resistance to paclitaxel, both in vitro and in vivo"


              Study Type: Interventional
              Study Design: Treatment

              Official Title: Phase II Study of Ixabepilone in Patients With Metastatic Cisplatin-Refractory Germ Cell Tumors

              Further study details as provided by National Cancer Institute (NCI):

              OBJECTIVES:

              Determine the efficacy of ixabepilone in patients with metastatic cisplatin-refractory germ cell tumors.
              Determine the safety of this drug in these patients.
              OUTLINE: Patients receive ixabepilone IV over 3 hours on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

              PROJECTED ACCRUAL: A total of 10-29 patients will be accrued for this study within 1.3-4 years.

              Eligibility

              Ages Eligible for Study: 16 Years and above, Genders Eligible for Study: Both
              Criteria
              DISEASE CHARACTERISTICS:

              Histologically confirmed germ cell tumor (GCT) (seminoma or non-seminoma) meeting the following criteria:
              Measurable metastatic disease by one of the following methods:
              Radiography
              If eligibility is defined by measurable disease only, there must be at least 1 site that has not been previously irradiated
              Alpha-fetoprotein greater than 15 ng/mL and/or ß-human chorionic gonadotropin greater than 2.2 mIU/L
              Previously treated progressive disease meeting 1 of the following criteria:
              Not a candidate for potentially curative therapy OR has already received high-dose chemotherapy regimens (prior paclitaxel allowed)
              Deemed to be cisplatin-refractory after prior cisplatin-based regimen AND does not want to have potentially curative high-dose therapy (mediastinal or primary refractory GCT)
              Prior treatment with 1 cisplatin-based regimen (primary mediastinal nonseminomatous GCT)
              PATIENT CHARACTERISTICS:

              Age

              16 and over
              Performance status

              Karnofsky 70-100%
              Life expectancy

              Not specified
              Hematopoietic

              Absolute neutrophil count at least 1,500/mm^3
              Platelet count greater than 100,000/mm^3
              Hemoglobin at least 10 g/dL
              Hepatic

              Bilirubin no greater than 1.5 times normal
              SGOT no greater than 2 times upper limit of normal
              Renal

              Creatinine no greater than 2.2 mg/dL
              Other

              Not pregnant or nursing
              Negative pregnancy test
              No active infection
              PRIOR CONCURRENT THERAPY:

              Biologic therapy

              No concurrent immunotherapy
              Chemotherapy

              See Disease Characteristics
              No other concurrent cytotoxic chemotherapy
              Endocrine therapy

              Not specified
              Radiotherapy

              See Disease Characteristics
              No concurrent radiotherapy
              Surgery

              Not specified
              Other

              No other concurrent experimental or commercial anticancer medications or therapies
              Last edited by danebert; 04-05-06, 10:46 PM.

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              • #8
                Hi.

                This might be a stretch to try but it might be an option. If he has solid tumors in his stomach, have him check into the Cyberknife procedure. It uses direct radiation aimed at the tumor only, and not the surrounding healthy cells, to kill the tumor.

                My husband had this done on a 5 inch tumor in his right lung (100% choriocarcinoma) and it killed the tumor; with no growth according to the Pet scan. He also had it done on marble size tumors in his brain. The technology can track moving organs in the body while it is moving.

                Maybe this could work for your friend, just to kill the tumors with direct beam of radiation. If it kills the cells, then he can get back on the treatment program.

                if you have questions, please let me know.

                Patti
                Wife of Kevin Murphy
                Diagnosed 7/16/04 100% Choriocarcinoma
                Oriechtomy 7/20/04
                4xBEP 8/04-11/04 BHCG:1200 (lung only)
                Rediagnosed 12/27/04 BHCG: 50
                1xVIP 1/05 (lung)
                HDC/Stem cell Indiana 2/05-4/05 BHCG: 51-4.5 (lung)
                HDC failure 5/05
                3xGemzar/Taxol 6/05-9/05 (lung only)
                VP-16 w/Avastin 9/05-1/06 (lung only)
                Cyberknife 5" lung tumor 2/06
                cyberknife 6 brain tumors 3/06
                1xOxaliplatnin 3/06 (liver, lungs, kidneys, left hip)
                Passed away 4/13/2006

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                • #9
                  thanks again everyone,its much appreciated.as of right now,he has not recieved a dose of BMS.He is on a morphine pump,and had to be intubated earlier due to a low blood pressure from the bleeding.The reason he didnt get the BMS is that he had to be off oral etoposide for at least one week before going for BMS.The oral etoposide really,just made him very very sick.He was vomiting constantly for the short time he was on it.He has also since had the nasophrangeal tubes removed,and his pressure is normal.They think the bleeding has stopped for now.Still radiation tomorrow.thanks
                  oh yes surgery is not an option yet....

                  Comment


                  • #10
                    Derek,
                    So sorry to hear all your buddy is going through. You're a good friend to him. I agree with Patti on looking into the Cyberknife. Stay strong, and my thoughts and prayers are with your buddy and you.
                    Retired moderator. Husband, left I/O 16Dec2005, stage I seminoma with elevated b-HCG, no LVI, RTx15 (25Gy). All clear ever since.

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                    • #11
                      went for radiation again today,felt better immediately.gamma knife radiation,being done at Yale closer to home.by the way Yale is building a 454 million dollar cancer center over the next 4 years,around 20 storys tall with the intentions of rivaling Sloan and Dana Farber.Anyways,pain subsided some,but he is ona morphine pump for the pain.liquid diet,and hes taking antibiotics for an upper respiratory tract infection.although he seems relatively strong still,he signed the DNR papers today and gave his father power of attourney.sucks.time is short,and everyone can feel it.i cant even begin to describe how horrible i feel for him,he has it the worst,but his mom and dad and family.its even worse cause when he was first diagnosed,the doctors almost reassured them by telling them close to 80%.if only he wasnt refractory.he was diagnosed late,but really what it breaks down to is that he wasnt a responder.really this kid is a warrior.he has literally exhausted every option possible,and may even still get BMS if the bleeding ever stops.his last x-rays were looking very bad however.tumor markers rising.all in all it seems as if its downhill from here.

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                      • #12
                        I'm so sorry.
                        Scott, [email protected]
                        right inguinal orchiectomy 6/5/2003 > nonseminoma, stage I > surveillance > L-RPLND 6/24/2005 for recurrence, suspected teratoma but found seminoma, stage II > chylous ascites until 9/2005 > surveillance and "all clear" since


                        Your donation funds Livestrong services for people facing cancer now. Please sponsor my ride!

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                        • #13
                          Derek:
                          I'm sorry to hear this. Stay strong your friend and his family will need your continued support.
                          Son Jason diagnosed 4/30/04, stage III. Right I/O 4/30/04. Graduated College 5/13/04. 4XEP 6/7/04 - 8/13/04. Full open RPLND 10/13/04. All Clear since.

                          Treated by Dr. Rakowski of Midland Park, NJ. Visited Sloan Kettering for protocol advice. RPLND done at Sloan Kettering.

                          Comment


                          • #14
                            Derek,
                            So sad to hear this. Stay strong for your buddy and his family and we'll be here for you as best we can. My prayers are with you for strength and your friend for comfort.
                            Retired moderator. Husband, left I/O 16Dec2005, stage I seminoma with elevated b-HCG, no LVI, RTx15 (25Gy). All clear ever since.

                            Comment


                            • #15
                              Derek:

                              I'm very sorry to hear this. You're an amazing friend and I'm sure your kindness and comfort are appreciated more than you know. Hang in there.

                              Jim
                              Fish
                              TC1
                              Right I/O 4/22/1988
                              RPLND 6/20/1988
                              TC2
                              Left I/O 9/17/2003
                              Surveillance

                              Tho' much is taken, much abides; and though we are not now that strength which in old days moved earth and heaven; that which we are, we are; one equal temper of heroic hearts, made weak by time and fate, but strong in will; to strive, to seek, to find, and not to yield.

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