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AFP increasing

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  • AFP increasing

    I got tumor markers done last Friday just prior to the start of the second round of BEP.

    Pre-surgery AFP was 25/hcg 200. Left orchiectomy on 1/7. Tumor was stage 1 with vascular invasion, predominantly seminoma w/small elements nonseminomas yolk sac and choriocarcinoma.

    Post surgery and pre chemo it had dropped. HCG was under 2, AFP down to 7.3 and LDH was at 140.

    After one round of BEP, HCG has stayed under 2. LDH has stayed within range but increased to 164. And AFP, which never made it to normal, has crept up to 10.4.

    Doctor and nurse tell me it's not a worry. It's possibly the result of the AFP test responding to my white blood cell response to allergies. I get another test tomorrow and next week.

    I realize this is really specific, but does anyone have thoughts on whether the doctor's explanation sounds reasonable and what I should be doing if the AFP and/or LDH continue going up?

    Many thanks.

  • #2
    Indiana University normal for AFP is less than 25. At our hospital in VT it is less than 10. When my husband's AFP wasn't normalizing the Doctor's wanted to see a few weeks of test to see the trend. We were also told that sometimes the markers will slightly spike after one round of chemo. I'm sure the AFP markers will continue to go down.
    Lori and Jon
    Diagnosed 5/22/2006
    I/O 5/26/2006, Stage 3, Good
    Teratoma (Majority), Seminoma (10%), Yolk Sac
    3xEP then determined not working
    HDC w/stem cell transplant 8/16/06 to 9/25/06
    Chest and Neck surgery 10/9/06 - immature teratoma
    RPLND 11/16/06 - immature Teratoma
    2/29/2008 - markers continue to be normal!
    9/16/2008 - released from Dr. Einhorn's care


    • #3
      Thanks Lori. That's interesting. My doctor uses under 6.1 as normal for AFP. I didn't realize there was such a spread in what could be considered normal.

      They also hadn't told me that the markers might go up without it being bad news. It would have been better to hear it beforehand. After the fact it just sounds like they're trying to pacify me so I won't worry.


      • #4
        Under 6 is normal however cancer isn't assumed until the number is over 25.
        Son Jason diagnosed 4/30/04, stage III. Right I/O 4/30/04. Graduated College 5/13/04. 4XEP 6/7/04 - 8/13/04. Full open RPLND 10/13/04. All Clear since.

        Treated by Dr. Rakowski of Midland Park, NJ. Visited Sloan Kettering for protocol advice. RPLND done at Sloan Kettering.


        • #5

          stay calm ! My AFP is very fluctuating : 2->8->3->6 etc
          [ooops no wine in my refrigerator !!!]
          Stage III EC 85% + Sem 15%
          AFP=2.6; HCG=10, 20,28 and rising
          FULL CAT scan:
          -abdominal lymph clear
          -subpleural lungs metastasis [bipulmonary lesions with diam <= 1cm]
          4 x BEP changed to 3 x BEP at my request
          from 2005-05....Surveillance


          • #6
            Many thanks for the input. AFP was down to 5 today. Even after 7 hours in the chair, when I got that report I was ready to dance home.