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AFP question

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  • AFP question

    These few posts with Tammy and Dawn have me wondering -

    Does anyone know what Sloan and Indiana use as a baseline for "normal" AFP? Rob's AFP was 14 two weeks before his surgery, and that was the last blood test that he received, which was also four weeks after his last round of chemo. So, as far as we knew, it was still dropping on its own.

    But there was a "dot" of live cancer left, which Sheinfeld removed during surgery. (I'm wondering if that could be possible with so low of an AFP)

    Sloan said they considered >15 a good number for sugery. But what do they consider a normal AFP, versus Indiana's normal? I know that different hospitals use different numbers.

    If anyone knows, thank you!! PS - Rob may be able to go home in two days! That will be three weeks exactly.
    Rob and Stacy
    DX: 3/10/05, AFP: 15,047, L I/O: 3/28/05, Yolk sac tumor & teratoma, Stage IIIC, 3xBEP & 1xEP: 4/4/07 - 6/25/07, AFP: 14, RPLND 8/10/07, w. left kidney removed. 10/19/07, AFP: 1.9

  • #2
    Brians Dr. told us that his HCG needs to be close to zero in order for them to do the surgery. I also heard that 15 was the amount for surgery, but i am thinking that is not true because his Dr. said he wanted his HCG lower

    Now i am confused too
    can someone help clarify mine and stacy's confusion

    Fiance Brian, dx:stage IIIC non-sem 4/18/07
    mets to lungs,liver,abdomin,large tumor near kidney
    hcg was 176,000!
    completed 1 rnd of TIP(had bad reaction to taxol)
    BEPx3 until 7/13/07
    7/26/07 post chemo ct-scan shwd shrinkage & fewer lung tumors
    10/17/07 @ MSKCC Liver FREE of cancer! necrotic & small focus of teratoma.
    AFP & HCG normal
    12/7/07 RPLND,right orchiectomy @ MSKCC
    12/18/07, rcvd pathology,all clear! no cancer!
    2/11/08 -Lung surgery dne @ MSKCC


    • #3
      I do not want to add to the confusion..but I thought under 6 was "normal" for AFP. Under .5 HCG is what our doctor says is 'normal'. We were told at SK that they would do the surgery if the AFP was under 15 for AFP. Above 15 and no surgery.
      Co-survivor with husband Boyce, Diagnosed 7-11-06, orchiectomy right testicle on 7-12-06- Stage 3A: Mixed germ cell tumor with inguinal seminomatous and kartotypic carcinoma. One tumor over 10 cm, second tumor 4 cm, Chemo 4xBEP: Bi-lateral RPLND Dec 2006, nerve sparing but left sterile.
      Current DVT
      Current testosterone replacement therapy, Testim.

      "You must abandon the life you planned, to live the life that was meant for you" ~wisdom I have learned from my family on this forum


      • #4
        My understanding is this.

        All the labs that have done markers for Anthony show a slightly different reference range for normal.

        Quest normal range for AFP is <6.1 ng/mL

        Quest normal range for HCG is <5 mIU/mL

        Hurley Medical Center normal AFP range is <5.5

        Hurley Medical Center normal HCG range is (this is what the sheet says)

        "Healthy males or non-preg. female show values less than 25

        Im not sure it its supposed to be .25 and maybe it didnt print out on the sheet.

        U of M normal range for AFP is 0.0 - 7.9 NG/ML
        U of M normal range for HCG is nondetectable to 5 mIU/mL

        My understanding is that certain things other than cancer can cause an elevated AFP or HCG, so some universities or cancer centers do not assume that the cause of the elevation is from cancer until it reaches a certain point. I think Indianas point is 20

        If Im wrong someone correct me, but this is how I understand it to be

        Son Anthony DX 12/11/06
        L/O 12/20/06 Stage IIIA, 95% EC, 5% Yolk Sac
        4XEP 1/29-4/6/ 07
        AFP started increasing3 wks later
        Residual abdominal mass found on CT
        RPLND 6/8/07
        Cancer in pathology-
        80% mature teratoma, 20% Yolk Sac. --
        No adjuvent chemo and
        AFP normalised

        July 22, 2010 ---- 3 years all clear!